The hepatoprotective effect of Carissa carandas Linn. (karanda in India) was evaluated based on its traditional uses and the reported phytocontituents26-54 in the CCl4 intoxicated rats ( CCl4 0.1 to 1 mg/kg body wt p.o.). For therapeutic study, test rats were dosed EECC (100 and 200 mg/kg body wt). The rats were sacrificed after 15 days of study before sacrifice the blood sample was collected from all rats of each group for estimation of serum enzymes, albumin, total protein and total lipid profiles. Standard kits were used for the tests (Baeyers Co. Ltd.2006) and the isolated livers were subjected to histopathological study and the results were compared with the standard herbal drug available in market i.e. Liv-52(0.125 mg/kg body wt., p.o dose/group). Significantly (p<0.01 or p<0.05) increase in serum levels, increase in lipid profile and decrease in total protein level were observed in control rats. Histopathological scanning showed cirrhosis like liver damage in CCl4 treated control group. These abnormalities were observed to be inhibited in EECC treated rats test rats and Liv-52 treated standard rats. Based on these results, it is considered that EECC due to its chemical constituents has favorable effects as a liver tonic.
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